Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation.

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

[How can young academics be recruited? Acceptance and effects of urological practice-oriented training]. / Nachwuchs gewinnen - aber wie? : Akzeptanz und Effekte eines urologischen Praxistrainings.

BACKGROUND: There is an increasing lack of young doctors in German hospitals, including urology departments. The aim of this study was to evaluate the benefit of urology practice-oriented courses for German students in a skills laboratory with respect to acceptance, learning success and enthusiasm of the students for urology. METHODS: Transurethral catheterization, digital rectal examination and kidney/bladder sonography were trained in the urology course. Using a 12-point questionnaire, acceptance and quality of the training were evaluated. Learning success was checked using a urological OSCE-station (Objective Structured Clinical Examination). Additionally, participants were questioned on interest in urology and the consideration of future work in the field (medical elective or practical year). RESULTS: A total of 147 questionnaires from 190 participating students were suitable for analysis. Acceptance and quality of training were highly ranked accompanied by a very satisfying objective and subjective learning success. Interest for urology was stimulated in 98.4 % and future work in urology was imaginable for 60.4 % of the students. DISCUSSION: Practice-oriented urology student courses show high acceptance, high learning success and increase of attractiveness of urology. The training of urological skills represents a sufficient tool to entice students for urology and is helpful in enhancing the future of urology.

Preliminary studies on the chemical properties of the toxic principle from Diamphidia nigroornata larvae, a source of Bushman arrow poison.

The Bushmen of southern Africa use the expressed contents of beetle larvae (Diamphidia, Lebistina and Polyclada species) as arrow poison. an aqueous extract of Diamphidia nigroornata larvae was fractionated by gel filtration on Sephadex G-50. Two fractions were obtained: one (I) of high molecular weight which contains a protein of 60 000 daltons, and a low molecular weight fraction (II) of non-protein nature. Both fractions proved to be lethal to mice: an LD50 of 0.5 - 0.95 (I) and 3.2 - 3.5 (II) mg/kg (intraperitoneal injection), respectively, was determined. The toxic principle of fraction I could be partly separated from the protein by ammonium sulfate precipitation followed by gel filtration. That of fraction II was further resolved into several subfractions by gel filtration of Sephadex G-10; however, the lethal activity was completely lost during purification. In thin-layer chromatography the low molecular weight toxin(s) did not react with reagents for steroids, alkaloids, sugars or terpenes, but showed a positive ninhydrin reaction. It is concluded that the toxic principle of the Bushman arrow poison is a highly labile, low molecular weight compound which is closely attached or bound to a protein protecting it from inactivation.